Editor's Note: Dominant-Negative Fas Mutation Is Reversed by Down-expression of c-FLIP
نویسندگان
چکیده
منابع مشابه
Dominant-negative Fas mutation is reversed by down-expression of c-FLIP.
Fas triggering by agonistic antibodies or by its cognate ligand, FasL, induces apoptotic cell death, whereas mutation in the Fas death domain is associated with lymphoma progression. On prolonged culture in the presence of an agonistic anti-Fas antibody, we raised a Jurkat cell line resistant to agonistic antibodies but still sensitive to soluble FasL, which carried at the heterozygous state, a...
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cAMP response element binding protein (CREB) is a critical regulator of diverse stimulus-dependent transcriptional events. Following TCR stimulation, CREB is rapidly induced in CD4+ Th cell precursors, but not in effector Th cells. However, its role in mature T cell function is incompletely defined. Transgenic mice expressing a CREB dominant-negative (dn) mutation in the T cell lineage exhibite...
متن کاملEditors note
EDITOR’S NOTE Geopersia is published biannually by the College of Science, University of Tehran, Iran. The College of Science published “Journal of Science”, which covered all fields of basic science, from 1968 to 2010. It was then decided that the College’s journals should be more specialized, and hence publication of Geopersia was launched. Geopersia aims to publish peer-reviewed original...
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AIMS AND BACKGROUND Mounting evidence indicates that evasion of apoptosis contributes to tumor pathogenesis. Although both Fas and Bcl-2 are crucial in apoptosis of normal ovarian cells, their roles in ovarian tumors, especially stromal tumors, are largely unknown. The aim of this study was to explore mutation of the Fas gene and expression of the apoptosis-related proteins Fas, FLICE-like inhi...
متن کاملeditors note
editor’s note geopersia is published biannually by the college of science, university of tehran, iran. the college of science published “journal of science”, which covered all fields of basic science, from 1968 to 2010. it was then decided that the college’s journals should be more specialized, and hence publication of geopersia was launched. geopersia aims to publish peer-reviewed original res...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2020
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-19-3174